What is the SLC gene?
Normal Function. Collapse Section. The SLC25A24 gene provides instructions for producing a protein that is a member of the solute carrier (SLC) family of proteins. Proteins in the SLC family transport various compounds across the membranes surrounding the cell and its component parts.
How many families are in SLC?
The solute carrier (SLC) group of membrane transport proteins include over 400 members organized into 66 families. Most members of the SLC group are located in the cell membrane.
How many Monocarboxylate transporters are there?
14
Monocarboxylate transporters (MCTs) are members of the solute carrier (SLC) family (SLC16) of proteins and are comprised of 14 isoforms.
What is full form of SLC?
SLC – School Leaving Certificate.
What are OATP1B1 inhibitors?
OATP1B1 and OATP1B3 are transporters that are expressed on the sinusoidal membrane of hepatocytes; they accept a number of therapeutic reagents as their substrates. In vitro and in vivo studies have shown that some drugs inhibit these transporters and cause clinically relevant drug-drug interactions (DDIs).
How do Monocarboxylate transporters work?
2.2. 2 Monocarboxylate transporters. Monocarboxylate transporters (MCTs) are other important plasma membrane transporters that catalyze the proton-linked transport of monocarboxylates such as lactate and pyruvate, which play a major role in cell metabolism and metabolic communication between tissues.
What is the function of Monocarboxylate transport proteins?
Monocarboxylate transporters (MCTs) catalyze the proton-linked transport of monocarboxylates such as L-lactate, pyruvate, and the ketone bodies across the plasma membrane. There are four isoforms, MCTs 1-4, which are known to perform this function in mammals, each with distinct substrate and inhibitor affinities.
What does SLC transporter mean?
Solute carrier
Solute carrier (SLC) transporters — a family of more than 300 membrane-bound proteins that facilitate the transport of a wide array of substrates across biological membranes — have important roles in physiological processes ranging from the cellular uptake of nutrients to the absorption of drugs and other xenobiotics.
What is SLC in business?
A synthetic letter of credit (SLC) is a pre-funded, negotiable instrument that guarantees a specified payment will be rendered. Letters of credit can be structured in a variety of ways. Broadly, the different types of letters of credit can be grouped into two categories: funded and unfunded.
What is the meaning of SCL?
SCL. Sulfur, Chlorine and Lead (extreme pressure additive) SCL. Scientific Computers Limited.
What does slc16 stand for?
Abstract The solute carrier family 16 (SLC16) is comprised of 14 members of the monocarboxylate transporter (MCT) family that play an essential role in the transport of important cell nutrients and for cellular metabolism and pH regulation.
Where can I find the slc16 gene family?
1 School of Biochemistry, Medical Sciences Building, University of Bristol, Bristol BS8 1TD, UK. a.hale[email protected] The SLC16 gene family has fourteen members.
What is the slc16 family of membrane proteins?
Conclusions and Future Studies The SLC16 family of transporters represents a significant group of 14 membrane proteins important for the disposition of both xenobiotics and endogenous compounds.
Is the MCT monocarboxylate transporter family slc16 involved in metabolic acidosis?
(2010b) Localization of members of MCT monocarboxylate transporter family Slc16 in the kidney and regulation during metabolic acidosis. Am J Physiol Renal Physiol299:F141–F154.