What is Antithymocyte globulin used for?
Anti-thymocyte globulin (rabbit) injection is used together with other medicines to prevent and treat the body from rejecting a transplanted kidney.
What class of drug is Antithymocyte globulin?
This medication is used to prevent and treat rejection of a kidney transplant. This medication belongs to a class of drugs known as immunosuppressants. It works by decreasing your body’s natural defense (immune system). This helps prevent your body from rejecting the kidney transplant so it can work normally.
What is rabbit Antithymocyte globulin?
Anti-thymocyte globulin is a sterilized solution made of the cells of rabbits that have been injected with white blood cells from humans. Anti-thymocyte globulin lowers your body’s immune system. The immune system helps your body fight infections.
What is AGT treatment?
Anti-Thymocyte Globulin (ATG) ATG is approved in the U.S. to treat acquired aplastic anemia and to reduce the chance of organ rejection after a kidney or other organ transplant. It may also be used to treat MDS or reduce rejection after a bone marrow transplant. In the U.S., it is also sold under the brand name AtgamĀ®.
What is the mechanism of action of tacrolimus?
Tacrolimus acts by reducing peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP-12 (FK506 binding protein) creating a new complex. This inhibits both T-lymphocyte signal transduction and IL-2 transcription.
How much does Antithymocyte globulin cost?
The costs for basiliximab and antithymocyte globulin were calculated based on average wholesale prices (AWP). The price of basiliximab was $1224 per dose and the price of antithymocyte globulin was $262.24 per 250 mg ampoule [9]. Other drugs.
How is Antithymocyte globulin made?
Background. Antithymocyte globulin is a hyperimmune globulin preparation made from plasma of rabbits or horses that have been immunized with human thymocytes or T cells. ATG is given by infusion only and leads to a rapid decrease in circulating T cells.
Is thymoglobulin an immunosuppressant?
Thymoglobulin was the first commercial rabbit-derived ATG to be introduced in Europe and the US in the 1980s. Due to its demonstrated efficacy as an immunosuppressive agent, it remains a commonly used ATG for induction therapy and treatment of other associated conditions, such as graft-vs.
Can ATG be given outpatient?
ATG is often given in the hospital, but can be given in an outpatient infusion center (if well-tolerated), allowing the person to go home afterwards.
What is the cost of ATG?
Cost of transplant is about 10-12 lac, whereas cost of ATG and cyclosporine course is about 5-9 lac (lower cost is with Indian brand of ATG).