How does McCune-Albright syndrome cause precocious puberty?
Girls with McCune-Albright syndrome may reach puberty early. These girls often have menstrual bleeding by age 2. This early onset of menstruation is believed to be caused by excess estrogen, a female sex hormone, produced by cysts that develop in one of the ovaries .
How do you confirm McCune-Albright syndrome?
Testing and diagnosis Your child’s doctor will conduct a complete physical examination to check for cafe-au-lait spots and other symptoms of McCune-Albright syndrome. An X-ray and bone scan will reveal whether fibrous dysplasia is present and blood tests will show whether certain hormone levels are elevated.
Who is affected by McCune-Albright syndrome?
McCune-Albright syndrome affects males and females in equal numbers. Precocious puberty is more common in females. The disorder is estimated to affect 1 in 100,000 to 1 in 1,000,000 individuals in the general population.
What causes McCune-Albright syndrome?
McCune-Albright syndrome is caused by a change in the GNAS1 gene . The change causes the GNAS1 gene to become more active than usual. The gene change is not inherited from the parents, nor is it present at the time of conception. The change actually occurs in an early cell division in the developing embryo.
What is Albright’s disease?
Albright syndrome: A genetic disorder of bones, skin pigmentation and hormonal problems with premature sexual development. Also called McCune-Albright syndrome and polyostotic fibrous dysplasia.
Is McCune-Albright syndrome curable?
Treatment is unique for each person diagnosed with McCune-Albright syndrome. There isn’t a cure for the condition and treatment aims to reduce symptoms. Treatment could include: Medicine to treat bone growth symptoms like bisphosphonates, which reduce the risk of bone fractures.
How is McCune-Albright syndrome treated?
The treatment options for PP associated with MAS have evolved over the last twenty plus years. Therapy in girls typically includes the use of an anti-estrogen, while treatment options in boys include an antiandrogen in combination with an aromatase inhibitor (Al).
Is fibrous dysplasia inherited?
The gene mutation associated with fibrous dysplasia occurs after conception, in the early stages of fetal development. Therefore, the mutation isn’t inherited from your parents, and you can’t pass it on to your children.
What are the causes of central precocious puberty?
What causes precocious puberty? It may be caused by tumors or growths on the ovaries, adrenal glands, pituitary gland, or brain. Other causes may include central nervous system problems, family history of the disease, or certain rare genetic syndromes. In many cases, no cause can be found for the disorder.
What is Albright’s syndrome?
Reviewed on 6/3/2021. 1/4. Albright syndrome: A genetic disorder of bones, skin pigmentation and hormonal problems with premature sexual development. Also called McCune-Albright syndrome and polyostotic fibrous dysplasia.
Can McCune-Albright syndrome be cured?
Does fibrous dysplasia get worse with age?
Pain is more likely to occur if the bone affected is one of the weight-bearing bones of the leg or pelvis. Pain caused by fibrous dysplasia generally begins as a dull ache that worsens with activity and lessens with rest. It can get progressively worse over time.