What polymers are used for drug delivery system?
The most common carriers for polymer therapeutics are HPMA (polymer-drug) and PEG (polymer-protein), but other systems studied include poly(glutamic acid), PEI, dextran, dextrin, chitosans, poly(l-lysine), and poly(aspartamides) as polymeric carriers (92).
Why are polymers used in controlled drug delivery system how effective are they?
Polymers are becoming very important in the drug delivery field. To control the drug release rate from the formulation, polymers are being used as the main tool. Polymers can be used as taste masking agents, to enhance stability of drug and to modify drug release characteristics.
Why are polymers used for drug delivery?
The main role of polymer is to protect drug from physiological environment and prolong release of drug to improve its stability. The drug is release from polymer by diffusion, degradation and swelling.
What are pharmaceutical polymers?
Polymers are widely used in pharmaceutical applications. Polymers could play different roles in the design of pharmaceutical dosage forms. They can be used as suspending, emulsifying, binding, and flocculating agents, and as adhesives, packaging, and coating materials.
What is a potential hazard of using polymers in drug delivery?
The NMs toxic effects might occur in the administration site or they can result from the nano-sized materials ability to cross biological barriers (mucosal barriers, air-blood barrier, blood-brain barrier, placenta barrier) reaching cells and tissues that are generally protected from bulk size materials (Buzea et al..
What is the use of polymers in medicine?
Their role as suture materials, tissue adhesives, and vascular grafts, materials for cosmetic implants, dental composites, contact and intraocular lenses, etc. The use of polymers in medicine is innumerable. orthopedic devices.
How do polymers release drugs?
For polymeric materials the mechanisms of drug release are normally directly linked to drug diffusion, dissolution, and degradation of the carrier matrix. However, other factors, such as interactions of the material and the drug, can also influence the release kinetics.
What is controlled release formulation?
The controlled release formulations prepared by nanoparticles whose size varies from 10 to 1000nm facilitate the sustained release of drugs over time which in turn decreases the frequency of drug administration and improves patient compliance.
What is the mechanism of controlled drug release?
There are many mechanisms by which the drug release can be controlled in a system: dissolution, diffusion, osmosis, partitioning, swelling, erosion, and targeting. They are dependent on the particular application and may act simultaneously or at different stages of a process of delivery.
What are polymeric nanoparticles in drug delivery?
Polymeric nanoparticles stand out as a key tool to improve drug bioavailability or specific delivery at the site of action. The versatility of polymers makes them potentially ideal for fulfilling the requirements of each particular drug-delivery system.
What is the role of polymers in drug delivery?
Polymers have played an integral role in the advancement of drug delivery technology by providing controlled release of therapeutic agents in constant doses over long periods, cyclic dosage, and tunable release of both hydrophilic and hydrophobic drugs.
How can biocompatible polymers improve drug delivery?
In targeted drug delivery systems the site of action should be clearly known. Biocompatible polymers provide better control over the toxicity of the samples; this leads to more reliable drug delivery and ensures pa- tient’s safety. Novel strategies like dendrimer synthesis and controlled polymerisation techniques are now well A. Srivastavaet al.
Why polymeric nanoparticles are used in drug carrier systems?
Polymers used in colloidal drug carrier systems, consisting of small particles, show great advantage in drug delivery systems be- cause of optimized drug loading and releasing property. Polymeric nano particulate systems are available in wide variety and have established chemistry.
What are polymer drug conjugates?
Polymer drug conjugates such as Zoladex, Lupron Depot, On Caspar PEG intron are used in treatment of prostate cancer and lymphoblastic leukemia. Polymeric Drug Delivery systems are being utilized for controlled drug delivery assuring patient compliance.