What is the pathophysiology of acute myelogenous leukemia?
Acute myeloid leukemia (AML) develops as the consequence of a series of genetic changes in a hematopoietic precursor cell. These changes alter normal hematopoietic growth and differentiation, resulting in an accumulation of large numbers of abnormal, immature myeloid cells in the bone marrow and peripheral blood.
What is AML with monocytic differentiation?
Most people with AML have a subtype called myeloid leukemia, which means the cancer is in the cells that normally produce neutrophils. Other patients have a type of AML called monoblastic or monocytic leukemia. In monocytic leukemia, the cells look like white blood cells called monocytes.
What causes acute monocytic leukemia?
Acute myeloid leukaemia (AML) is caused by a DNA mutation in the stem cells in your bone marrow that produce red blood cells, platelets and infection-fighting white blood cells. The mutation causes the stem cells to produce many more white blood cells than are needed.
What is pathophysiology of leukemia?
Pathophysiology. Leukemia occurs due to the malignant transformation of pluripotent (i.e., can give rise to both myeloid and lymphoid precursors) hematopoietic stem cells. Rarely, it can also involve a more committed stem cell that has a limited self-renewal capacity.
How common is monocytic leukemia?
Chronic myelomonocytic leukemia (CMML) is rare, only occurring in 4 of every million people in the United States each year. That works out to about 1,100 cases each year. This disease is rare in young people. Almost 9 of 10 of cases are diagnosed in people 60 and older.
What are the symptoms of monocytic leukemia?
What are the symptoms of acute monocytic leukemia?
- bleeding disorders.
- bleeding under skin or gums.
- easy bruising or bleeding.
- shortness of breath.
- feeling of weakness.
- loss of weight and appetite.
Is acute monocytic leukemia curable?
Although AML is a serious disease, it is treatable and often curable with chemotherapy with or without a bone marrow/stem cell transplant (see the Types of Treatment section).
What do the different stages of leukemia mean?
– Lymphocytosis, which means there are high levels of lymphocytes in the blood – Lymphadenopathy, meaning a patient has enlarged lymph nodes – Splenomegaly, which is an enlarged spleen – Anemia, meaning low levels of red blood cells – Thrombocytopenia, meaning low levels of platelets – Hepatomegaly, which is an enlarged liver
What are the signs of leukemia?
– Night sweats – Discomfort in bones or joints – Enlarged spleen, liver or lymph nodes – Pain or feeling of fullness below the ribs – Unexplained weight loss or loss of appetite – Wheezing, coughing or painful breathing
What are the symptoms of end stage leukemia?
profound weakness and exhaustion
What are the symptoms of acute myeloid leukemia?
Bleeding that’s hard to stop