What is pamidronate disodium used for?
Pamidronate is used to treat high levels of calcium in the blood that may be caused by certain types of cancer.
How does calcitonin treat hypercalcemia?
In response to hypercalcemia, calcitonin is secreted by the parafollicular C cells. Calcitonin lowers serum calcium by decreasing renal calcium and phosphorus reabsorption and also by decreasing bone reabsorption. Calcitonin is not significant in overall calcium homeostasis, but it is an important therapeutic option.
How do bisphosphonates inhibit osteoclast activity?
Bisphosphonates also reduce osteoclast activity by decreasing osteoclast progenitor development and recruitment and by promoting osteoclast apoptosis . In addition to their inhibitory effect on osteoclasts, bisphosphonates appear to have a beneficial effect on osteoblasts.
How long does pamidronate take to work?
It may take up to 7 days before the full benefit of this drug takes effect. Tell your doctor if your condition does not improve or if it worsens.
How do bisphosphonates work?
Bisphosphonates are drugs that target areas of higher bone turnover. The osteoclast cells, which break down old bone, absorb the bisphosphonate drug. Their activity is slowed down. This reduces bone breakdown.
What is zoledronic acid intravenous used for?
Zoledronic acid (Zometa) is used to treat high levels of calcium in the blood that may be caused by certain types of cancer.
What is the mechanism of action of calcitonin?
Calcitonin reduces calcium levels in the blood by two main mechanisms: It inhibits the activity of osteoclasts, which are the cells responsible for breaking down bone. When bone is broken down, the calcium contained in the bone is released into the bloodstream.
What is the mechanism of action of risedronate?
Risedronate is a heterocyclic orally active aminobisphosphonate and it belongs to the bisphosphonate category: these drugs are powerful bone resorption inhibitors, thanks to their affinity for hydroxyapatite crystals at bone mineral matrix level and to their inhibiting effects on osteoclast activity, using the ability …
When are bisphosphonates contraindicated?
Avoid oral bisphosphonates in patients with esophageal disorders such as achalasia, esophageal stricture, esophageal varices, Barrett’s esophagus, inability to stand or sit upright for at least 30 minutes, history of bariatric surgery (Roux-en-Y gastric bypass).
Does pamidronate affect teeth?
In the present study, pamidronate administration not only inhibited tooth eruption but also negatively affected mandibular growth pattern. Mandibular height and length of the study groups were statistically shorter than the control groups.
How long does a pamidronate last?
The standard infusion lasts 4 hours if there are no signs of reaction. The length of infusion can be adjusted if needed. Tell the nurse if your child has flu-like symptoms during the infusion and they will be given medicines as needed.
How many mg of pamidronate disodium are in pamisol?
Pamidronate disodium. Each mL of Pamisol 15 mg/5 mL and 30 mg/10 mL concentrated injection contains 3 mg pamidronate disodium. Each mL of Pamisol 60 mg/10 mL concentrated injection contains 6 mg pamidronate disodium. Each mL of Pamisol 90 mg/10 mL concentrated injection contains 9 mg pamidronate disodium.
What is the mechanism of action of pamidronate disodium?
Pamidronate disodium is a potent inhibitor of osteoclastic bone resorption. This antiresorptive activity is responsible for its therapeutic effect. Pamidronate disodium inhibits the formation and dissolution of calcium apatite crystals in vitro.
Is pamidronate disodium carcinogenic?
Pamidronate disodium by daily oral administration was not carcinogenic in an 80 week or a 104 week study in mice. Mannitol, phosphoric acid and/or sodium hydroxide (for pH adjustment), water for injections. Pamisol should not be added to intravenous infusion fluids containing calcium, such as Ringer’s solution and Hartmann’s solution.
What is the chemical name of the compound pamisol?
PAMISOL is a clear colourless solution. PAMISOL contains 3, 6, or 9 mg/mL of disodium pamidronate as the active ingredient. phosphoric acid or sodium hydroxide.