What conditions cause stomatocytes?
Stomatocytes have been noted in diverse acquired conditions, including neoplasms, cardiovascular and hepatobiliary disease, alcoholism, and therapy with drugs, some of which are known to be stomatocytogenic in vitro.
What is stomatocytes blood test?
Stomatocytes are red blood cells (rbcs) with an oval or rectangular area of central pallor, looking like a “mouth” on a stained blood smear differential. The indentation on one side of the red cell is missing. Stomatocytes usually have altered permeability and increased cell volume.
What disorder occurs when erythrocytes produced have an irregular shape?
These unusually shaped cells give the disease its name. Sickle cell anemia is one of a group of disorders known as sickle cell disease. Sickle cell anemia is an inherited red blood cell disorder in which there aren’t enough healthy red blood cells to carry oxygen throughout your body.
What causes stomatocytes in blood smear?
Stomatocytes can be seen with some acquired conditions such as chronic liver disease (most often due to alcoholism) or acute alcohol intoxication. The stomatocytosis with acute alcohol intoxication appears to be transient, and it may affect a significant proportion of RBCs.
What causes acanthocytes blood?
Acanthocytosis is thought to result from an imbalance of cholesterol and phospholipid on the blood cell membranes. It can be reversed with a liver transplant. Spleen removal. Splenectomy is often associated with acanthocytosis.
What is a Stomatocyte on a smear?
STOMATOCYTES “Stomatocyte” describes the appearance of red blood cells (RBCs) on the peripheral blood smear. Stomatocytes (also called hydrocytes) contain a mouthlike or slitlike pattern that replaces the normal central zone of pallor.
What causes stomatocytosis in peripheral blood smear?
Several rare inherited defects affecting membrane lipid composition have been reported to have stomatocytosis on the peripheral blood smear. Liver disease/medications. Stomatocytes can be seen with some acquired conditions such as chronic liver disease (most often due to alcoholism) or acute alcohol intoxication.
What is stomatocytosis?
Typical red blood cells are known as stomatocytes (mouth featured cells) appear in blood smear examination. The clinical manifestation can vary from asymptomatic to severe hemolytic anemia. Hereditary Stomatocytosis shows autosomal dominant inheritance and may cause severe hemolytic anemia presenting very early in life.
What causes large numbers of stomatocytes in the blood?
Large numbers of stomatocytes are associated with very rare hereditary disorders of red cell cation permeability leading to increased or decreased red cell water content. Hereditary Stomatocytosis comprises two different diseases: the xerocytosis or dehydrated hereditary stomatocytosis and the overhydrated hereditary stomatocytosis.