How does spironolactone affect breast?
This medicine may cause swelling of the breasts (gynecomastia) and breast pain in some patients. If you have questions about this, talk to your doctor.
How does spironolactone cause breast enlargement?
Breast changes Spironolactone frequently causes breast pain and breast enlargement in women. This is “probably because of estrogenic effects on target tissue.” At low doses, breast tenderness has been reported in only 5% of women, but at high doses, it has been reported in up to 40% of women.
How does spironolactone cause gynecomastia?
Spironolactone induces gynecomastia by decreasing testosterone production, increasing peripheral conversion of testosterone to estradiol, and displacing estradiol from sex hormone-binding globulin. Generally, discontinuation of treatment results in resolution of gynecomastia.
Does testosterone make your breast hurt?
As testosterone levels drop in older men, gynecomastia may develop and persist unless it’s treated. Gynecomastia affects about 1 in 4 men between the ages of 50 and 80, according to the Mayo Clinic. The condition usually isn’t harmful or serious. In some cases, it can result in sore breast tissue.
Can too much testosterone cause sore nipples?
In our practices, it was observed that patients develop tender nipples from gynecomastia after injectable testosterone therapy. This could be the result of increased testosterone levels after treatment, which in turn aromatizes into E2.
Can spironolactone cause sore breasts in men?
Spironolactone may cause swelling of the breasts (gynecomastia) and breast pain in some patients.
Does spironolactone make you feminine?
Feminizing hormone therapy often involves taking estrogen and anti-androgen hormones, such as estradiol or spironolactone. By taking these hormones, you may be able to achieve more traditionally feminine characteristics, including breast growth, body fat redistribution, and less facial hair.
Does spironolactone cause tender breasts?
Spironolactone causes breast tenderness and enlargement, mastodynia, infertility, chloasma, altered vaginal lubrication, and reduced libido in women, probably because of estrogenic effects on target tissue.